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Xaa-Xaa-Pro tripeptidyl-peptidase

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Xaa-Xaa-Pro tripeptidyl-peptidase
Identifiers
EC no.3.4.14.12
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins

Xaa-Xaa-Pro tripeptidyl-peptidase (EC 3.4.14.12, prolyltripeptidyl amino peptidase, prolyl tripeptidyl peptidase, prolyltripeptidyl aminopeptidase, PTP-A, TPP) is an enzyme.[1][2] It catalyses the following chemical reaction

Hydrolysis of Xaa-Xaa-Pro!Yaa- releasing the N-terminal tripeptide of a peptide with Pro as the third residue (position P1) and where Yaa is not proline

This cell-surface-associated serine exopeptidase is found in the Gram-negative, anaerobic bacterium Porphyromonas gingivalis.

References

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  1. ^ Banbula A, Mak P, Bugno M, Silberring J, Dubin A, Nelson D, Travis J, Potempa J (April 1999). "Prolyl tripeptidyl peptidase from Porphyromonas gingivalis. A novel enzyme with possible pathological implications for the development of periodontitis". The Journal of Biological Chemistry. 274 (14): 9246–52. doi:10.1074/jbc.274.14.9246. PMID 10092598.
  2. ^ Fujimura S, Ueda O, Shibata Y, Hirai K (February 2003). "Isolation and properties of a tripeptidyl peptidase from a periodontal pathogen Prevotella nigrescens". FEMS Microbiology Letters. 219 (2): 305–9. doi:10.1016/s0378-1097(03)00048-x. PMID 12620636.
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