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WBP2

From Wikipedia, the free encyclopedia
WBP2
Identifiers
AliasesWBP2, WBP-2, GRAMD6, WW domain binding protein 2, DFNB107
External IDsOMIM: 606962; MGI: 104709; HomoloGene: 32160; GeneCards: WBP2; OMA:WBP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012478
NM_001330499
NM_001348170

NM_016852
NM_001347642
NM_001361446

RefSeq (protein)

NP_001317428
NP_036610
NP_001335099

NP_001334571
NP_058548
NP_001348375

Location (UCSC)Chr 17: 75.85 – 75.86 MbChr 11: 115.97 – 115.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

WW domain-binding protein 2 is a protein that in humans is encoded by the WBP2 gene.[5][6]

The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by its PY motifs. The function of this protein has not been determined.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132471Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034341Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chen HI, Sudol M (Sep 1995). "The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules". Proc Natl Acad Sci U S A. 92 (17): 7819–23. Bibcode:1995PNAS...92.7819C. doi:10.1073/pnas.92.17.7819. PMC 41237. PMID 7644498.
  6. ^ a b "Entrez Gene: WBP2 WW domain binding protein 2".

Further reading

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