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Vestigial-like family member 3

From Wikipedia, the free encyclopedia

VGLL3
Identifiers
AliasesVGLL3, VGL-3, VGL3, Vestigial-like family member 3, vestigial like family member 3
External IDsOMIM: 609980; MGI: 1920819; HomoloGene: 53442; GeneCards: VGLL3; OMA:VGLL3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016206
NM_001320493
NM_001320494

NM_028572
NM_001368760
NM_001368761

RefSeq (protein)

NP_001307422
NP_001307423
NP_057290

NP_082848
NP_001355689
NP_001355690

Location (UCSC)Chr 3: 86.88 – 86.99 MbChr 16: 65.61 – 65.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Vestigial-like family member 3 is a protein that in humans is encoded by the VGLL3 gene.[5]

This protein is one of four mammalian homologs (VGLL1-4) of the vestigial gene found in the fruit fly Drosophila.[6] VGLL3 functions as a transcription coregulator by binding to TEA domain (TEAD) transcription factors (TEAD1, TEAD2, TEAD3, TEAD4 ) through its TDU motif.[6][7] VGLL3 has been implicated in various biological processes including myogenesis (formation of muscle tissue), cell proliferation, and cancer progression.[7] VGLL3 can also promote epithelial-to-mesenchymal transition (EMT) and cell motility in certain cancer types, suggesting it may play a role in tumor development and metastasis.[7]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000206538Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000091243Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Vestigial-like family member 3".
  6. ^ a b Yamaguchi N (2020). "Multiple Roles of Vestigial-Like Family Members in Tumor Development". Frontiers in Oncology. 10: 1266. doi:10.3389/fonc.2020.01266. PMC 7393262. PMID 32793503.
  7. ^ a b c Hori N, Takakura Y, Sugino A, Iwasawa S, Nomizo K, Yamaguchi N, et al. (May 2022). "Vestigial-like family member 3 stimulates cell motility by inducing high-mobility group AT-hook 2 expression in cancer cells". Journal of Cellular and Molecular Medicine. 26 (9): 2686–2697. doi:10.1111/jcmm.17279. PMC 9077286. PMID 35366053.

Further reading

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