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Tyrosine decarboxylase

From Wikipedia, the free encyclopedia
tyrosine decarboxylase
Identifiers
EC no.4.1.1.25
CAS no.9002-09-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme tyrosine decarboxylase (EC 4.1.1.25) catalyzes the chemical reaction

L-tyrosine tyramine + CO2

Hence, this enzyme has one substrate, L-tyrosine, and two products, tyramine and carbon dioxide.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is L-tyrosine carboxy-lyase (tyramine-forming). Other names in common use include L-tyrosine decarboxylase, L-(−)-tyrosine apodecarboxylase, and L-tyrosine carboxy-lyase. This enzyme participates in tyrosine metabolism and alkaloid biosynthesis. It employs one cofactor, pyridoxal phosphate.

References

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  • McGilvery RW, Cohen PP (July 1948). "The decarboxylation of L-phenylalanine by Streptococcus faecalis R". The Journal of Biological Chemistry. 174 (3): 813–6. PMID 18871240.