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Linkers

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Need more on the linkers eg MCC, what they are, how they dissolve ... Rod57 (talk) 09:39, 18 January 2011 (UTC)[reply]

One source Antibody−Drug Conjugates: Linking Cytotoxic Payloads to Monoclonal Antibodies. 2010 not free.

It seems SeaGens linkers are non-cleavable which can sometimes be advantageous.Seattle Genetics and Genentech. Rod57 (talk) 11:29, 29 April 2011 (UTC)[reply]

ADCs using paclitaxel

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ADCs using paclitaxel : Synthesis and Preliminary Biological Evaluation of High-drug Load Paclitaxel-Antibody Conjugates for Tumor-targeted Chemotherapy. Rod57 (talk) 00:38, 24 March 2011 (UTC)[reply]

AN-152 not an ADC

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The toxin is targeted by linking it to LHRH which binds to LHRH receptors on the target cells. Is there a name for this type of targeted therapy ? - Rod57 (talk) 12:27, 14 June 2011 (UTC)[reply]

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Sometimes (as in Epratuzumab-SN-38: a new antibody-drug conjugate for the therapy of hematological malignancies) a less stable link is better when the drug/target is more rapidly internalised. - Rod57 (talk) 17:10, 31 October 2011 (UTC)[reply]

Major changes - not discussed

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Sometime in 2013 it looks like there have been major changes with a lot of content removed without any apparent discussion here. I'd like to reinstate the lists of ADCs in clinical trials - here or should it be in a separate article ? - Rod57 (talk) 13:07, 12 August 2014 (UTC)[reply]

The pre-June 2013 old page seemed NPOV but the new page seems very POV with unjustified omissions and change of emphasis. Looks like much of the new material has been based on marketing materials or advertisements from one of the ADC vendors. Needs more investigation. - Rod57 (talk) 13:01, 21 April 2015 (UTC)[reply]

IMMU-132 etc for list

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Preclinical

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[3] mentions HDCs (Humabody-DC) based on VH fragments. - Rod57 (talk) 16:31, 15 February 2016 (UTC)[reply]

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Lancet

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For cancer doi:10.1016/S0140-6736(19)31774-X JFW | T@lk 07:52, 2 September 2019 (UTC)[reply]

Problem in the article: creating the abbreviation iADC but not explaining it

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Right now the wikipedia article has this:

"The first immunology antibody-drug conjugate (iADC), ABBV-3373, is undergoing clinical trials for participants with moderate to severe rheumatoid arthritis.[16]"

I tried to search for iADC, and found the abbreviation a few times (via google search) - but never a clear definition of that abbreviation. I believe wikipedia needs to adhere to stricter standards, and define such articles. Right now it reads a bit like an advertisement; I think what has to happen is to define the word, also add who coined it if possible, and when. It is not a good idea to add new articles, but not explain them, or link to in-wikipedia to explain that article on wikipedia. Right now (January 2020) we do not have any explanation for that term iADC, which is not ideal in my opinion. 2A02:8388:1641:8380:E1C:C3B5:304A:1703 (talk) 21:20, 30 January 2020 (UTC)[reply]