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TAF12

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TAF12
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTAF12, TAF2J, TAFII20, TATA-box binding protein associated factor 12
External IDsOMIM: 600773; MGI: 1913714; HomoloGene: 68477; GeneCards: TAF12; OMA:TAF12 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001135218
NM_005644

NM_025579

RefSeq (protein)

NP_001128690
NP_005635

NP_079855

Location (UCSC)Chr 1: 28.59 – 28.65 MbChr 4: 132 – 132.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription initiation factor TFIID subunit 12 is a protein that in humans is encoded by the TAF12 gene.[5][6]

Function

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Control of transcription by RNA polymerase II involves the basal transcription machinery, which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes that are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached, whereas others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I.[6]

Interactions

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TAF12 has been shown to interact with TAF9[7] and Transcription initiation protein SPT3 homolog.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120656Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028899Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mengus G, May M, Jacq X, Staub A, Tora L, Chambon P, Davidson I (May 1995). "Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID". EMBO J. 14 (7): 1520–31. doi:10.1002/j.1460-2075.1995.tb07138.x. PMC 398239. PMID 7729427.
  6. ^ a b "Entrez Gene: TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa".
  7. ^ a b Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (October 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Mol. Cell. Biol. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856. PMID 11564863.

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: Q16514 (Transcription initiation factor TFIID subunit 12) at the PDBe-KB.