Jump to content

Susan Lovett

From Wikipedia, the free encyclopedia

Susan Thomas Lovett
Born
Alma materCornell University
University of California, Berkeley
Scientific career
InstitutionsBrandeis University
Lawrence Berkeley National Laboratory
ThesisThe recJ gene of Escherichia coli (1983)

Susan Thomas Lovett is an American molecular biologist who is the Abraham S. and Gertrude Burg Professor of Microbiology at Brandeis University. She is interested in the mechanisms that allow the genetic material in cells to remain stable over time.

Early life and education

[edit]

Lovett was born in Rochester, New York.[1] She spent her childhood in Virginia and Ohio.[1] Lovett was an undergraduate student at Cornell University.[2] She moved to the University of California, Berkeley for her doctoral research, where she investigated Escherichia coli.[3] She was a postdoctoral researcher at Lawrence Berkeley National Laboratory.[1]

Research and career

[edit]

Lovett joined Brandeis University in 1989.[4] She is a molecular biologist who studies the mechanisms that underpin DNA repair. In particular, Lovett has studied how cells protect their genetic information and avoid genetic mutation. These strategies help to tackle cancer and prevent cells from ageing. She has worked on the model organism Escherichia coli since the beginning of her career, and identified a secondary DNA damage response that is independent of the well-documented SOS response.[5] Lovett identified many of the enzymes involves with DNA repair, including the post-transcriptional regulatory protein IraD, the ExoX and RecJ exonucleases, the Eubacterial protein RadA/Sms and the DNA helicase YoaA.[5]

Amongst the repair mechanisms, Lovett has studied mutagenesis at the replication fork and how it coordinates with cellular cycles. She identified a GTPase proteins that couples cellular division with events at the replication fork. She has shown that chain-terminating drugs can be used, for example the AIDS drug, azidothymadine) to accumulate replication gaps, and that cellular nutrition impacts replication and repair.[4]

Lovett has investigated the mutational hotspots that occur when strands of DNA do not align during the replication processes. Aberrant replication results in the rearrangement of DNA, which impacts the formation of mutational hotspots and exonuclease.[6]

From 2006 to 2010, Lovett taught on the Cold Spring Harbor Laboratory course in Advanced Bacterial Genetics.[1]

Awards and honors

[edit]

Selected publications

[edit]

References

[edit]
  1. ^ a b c d "Susan T. Lovett". www.nasonline.org. Retrieved December 28, 2021.
  2. ^ a b "Susan Lovett | Brandeis University". www.brandeis.edu. Retrieved December 28, 2021.
  3. ^ Lovett, Susan Thomas (1983). The recJ gene of Escherichia coli. OCLC 905884470.
  4. ^ a b c "Professors Anita Hill and Susan Lovett elected to American Academy of Arts and Sciences". BrandeisNOW. Retrieved December 28, 2021.
  5. ^ a b "EcoSal Plus". EcoSal Plus. 2020. doi:10.1128/ecosalplus. Retrieved December 28, 2021.
  6. ^ "Susan Lovett". www.brandeis.edu. Archived from the original on December 28, 2021. Retrieved December 28, 2021.
  7. ^ "Genetics Society of America Announces 2011 Board Members". www.newswise.com. Archived from the original on December 28, 2021. Retrieved December 28, 2021.
  8. ^ "AAAS Members Elected as Fellows | American Association for the Advancement of Science". www.aaas.org. Archived from the original on December 9, 2021. Retrieved December 28, 2021.
  9. ^ "School of Arts & Sciences Faculty Service Award". www.brandeis.edu. Archived from the original on December 28, 2021. Retrieved December 28, 2021.
  10. ^ "Susan Lovett elected to National Academy of Sciences". BrandeisNOW. Archived from the original on December 28, 2021. Retrieved December 28, 2021.