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Spleen exonuclease

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Spleen exonuclease
Identifiers
EC no.3.1.16.1
CAS no.9068-54-6
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IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
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Spleen exonuclease (EC 3.1.16.1, 3'-exonuclease, spleen phosphodiesterase, 3'-nucleotide phosphodiesterase, phosphodiesterase II) is an enzyme.[1] This enzyme catalyses the following chemical reaction

Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 3'-phosphates (exonuclease type b)

This enzyme has a preference for single-stranded substrate.

PLD3 and/or PLD4 might be the genes encoding spleen exonuclease, as they have similar substrate specificity and tissue distribution.[2]

References

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  1. ^ Bernardi A, Bernardi G (1971). "Spleen acid nuclease". In Boyer PD (ed.). The Enzymes. Vol. 4 (3rd ed.). New York: Academic Press. pp. 329–336.
  2. ^ Gavin AL, Huang D, Huber C, Mårtensson A, Tardif V, Skog PD, et al. (September 2018). "PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing". Nature Immunology. 19 (9): 942–953. doi:10.1038/s41590-018-0179-y. PMC 6105523. PMID 30111894.
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