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PRKX

From Wikipedia, the free encyclopedia
PRKX
Identifiers
AliasesPRKX, PKX1, protein kinase, X-linked, protein kinase X-linked
External IDsOMIM: 300083; MGI: 1309999; HomoloGene: 55868; GeneCards: PRKX; OMA:PRKX - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005044

NM_016979

RefSeq (protein)

NP_005035
NP_005035.1

NP_058675

Location (UCSC)Chr X: 3.6 – 3.71 MbChr X: 76.81 – 76.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein kinase, X-linked is a protein that in humans is encoded by the PRKX gene. [5]

Function

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This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y.

Nomenclature

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Mouse ortholog for this gene, Prkx, is also known as Pkare.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183943Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035725Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Protein kinase, X-linked". Retrieved 2017-05-19.
  6. ^ "Prkx protein kinase, X-linked [ Mus musculus (house mouse) ]". National Center for Biotechnology Information.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.