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POLR3F

From Wikipedia, the free encyclopedia
POLR3F
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPOLR3F, RPC39, RPC6, polymerase (RNA) III subunit F, RNA polymerase III subunit F, C34
External IDsOMIM: 617455; MGI: 1924086; HomoloGene: 4722; GeneCards: POLR3F; OMA:POLR3F - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282526
NM_006466

NM_029763
NM_027417

RefSeq (protein)

NP_001269455
NP_006457

NP_084039

Location (UCSC)Chr 20: 18.47 – 18.48 MbChr 2: 144.37 – 144.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DNA-directed RNA polymerase III subunit RPC6 is an enzyme that in humans is encoded by the POLR3F gene.[5][6]

Function

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The protein encoded by this gene is one of more than a dozen subunits forming eukaryotic RNA polymerase III (RNA Pol III), which transcribes 5S ribosomal RNA and tRNA genes. This protein has been shown to bind both TFIIIB90 and TBP, two subunits of RNA polymerase III transcription initiation factor IIIB (TFIIIB). Unlike most of the other RNA Pol III subunits, the encoded protein is unique to this polymerase.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132664Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027427Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wang Z, Roeder RG (May 1997). "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation". Genes & Development. 11 (10): 1315–26. doi:10.1101/gad.11.10.1315. PMID 9171375.
  6. ^ a b "Entrez Gene: POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa".

Further reading

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