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PDCD5

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PDCD5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPDCD5, TFAR19, programmed cell death 5
External IDsOMIM: 604583; MGI: 3782009; HomoloGene: 10506; GeneCards: PDCD5; OMA:PDCD5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004708

XM_001478256

RefSeq (protein)

NP_004699

NP_062720

Location (UCSC)Chr 19: 32.58 – 32.59 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Programmed cell death protein 5 is a protein, originally identified as an apoptosis-accelerating protein,[4] that in humans is encoded by the PDCD5 gene.[5][6]

This gene encodes a protein expressed in tumor cells during apoptosis independent of the apoptosis-inducing stimuli. Prior to apoptosis induction, this gene product is distributed in both the nucleus and cytoplasm.

Once apoptosis is induced, the level of this protein increases and by relocation from the cytoplasm, it accumulates in the nucleus. Although its exact function is not defined, this protein is thought to play an early and universal role in apoptosis.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105185Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Li G, Ma D, Chen Y (April 2016). "Cellular functions of programmed cell death 5". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1863 (4): 572–580. doi:10.1016/j.bbamcr.2015.12.021. PMID 26775586.
  5. ^ Liu H, Wang Y, Zhang Y, Song Q, Di C, Chen G, Tang J, Ma D (January 1999). "TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal". Biochemical and Biophysical Research Communications. 254 (1): 203–210. doi:10.1006/bbrc.1998.9893. PMID 9920759.
  6. ^ a b "Entrez Gene: PDCD5 programmed cell death 5".

Further reading

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