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PASD1

From Wikipedia, the free encyclopedia

PASD1
Identifiers
AliasesPASD1, CT63, OXTES1, PAS domain containing 1, PAS domain containing repressor 1, CT64
External IDsOMIM: 300993; HomoloGene: 131196; GeneCards: PASD1; OMA:PASD1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_173493

n/a

RefSeq (protein)

NP_775764

n/a

Location (UCSC)Chr X: 151.56 – 151.68 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

PAS domain-containing protein 1 is a protein that in humans is encoded by the PASD1 gene.[3][4][5]

PASD1 has been shown to inhibit the transcriptional activity between CLOCK and BMAL1 which appears to be co-opted in cancer cells to attenuate clock function.[6][7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166049Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Liggins AP, Guinn BA, Hatton CS, Pulford K, Banham AH (July 2004). "Serologic detection of diffuse large B-cell lymphoma-associated antigens". International Journal of Cancer. 110 (4): 563–569. doi:10.1002/ijc.20170. PMID 15122589.
  4. ^ Liggins AP, Brown PJ, Asker K, Pulford K, Banham AH (July 2004). "A novel diffuse large B-cell lymphoma-associated cancer testis antigen encoding a PAS domain protein". British Journal of Cancer. 91 (1): 141–149. doi:10.1038/sj.bjc.6601875. PMC 2364759. PMID 15162151.
  5. ^ "Entrez Gene: PASD1 PAS domain containing 1".
  6. ^ Michael AK, Harvey SL, Sammons PJ, Anderson AP, Kopalle HM, Banham AH, Partch CL (June 2015). "Cancer/Testis Antigen PASD1 Silences the Circadian Clock". Molecular Cell. 58 (5): 743–754. doi:10.1016/j.molcel.2015.03.031. PMC 4458219. PMID 25936801.
  7. ^ Greenwood V (15 September 2015). "How the Body's Trillions of Clocks Keep Time". Quanta Magazine.

Further reading

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