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Neolactotetraosylceramide alpha-2,3-sialyltransferase

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neolactotetraosylceramide alpha-2,3-sialyltransferase
Identifiers
EC no.2.4.99.10
CAS no.83745-06-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a neolactotetraosylceramide alpha-2,3-sialyltransferase (EC 2.4.99.10) is an enzyme that catalyzes the chemical reaction

CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D- galactosyl-1,4-D-glucosylceramide CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D- glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide

The 3 substrates of this enzyme are CMP-N-acetylneuraminate, beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-, and galactosyl-1,4-D-glucosylceramide, whereas its 3 products are CMP, alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-, and glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide.

This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:neolactotetraosylceramide alpha-2,3-sialyltransferase. Other names in common use include cytidine monophosphoacetylneuraminate-neolactotetraosylceramide, sialyltransferase, sialyltransferase 3, and SAT-3. This enzyme participates in glycosphingolipid biosynthesis - neo-lactoseries and glycan structures - biosynthesis 2.

References

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  • Basu M, Basu S, Stoffyn A, Stoffyn P (1982). "Biosynthesis in vitro of sialyl(alpha 2-3)neolactotetraosylceramide by a sialyltransferase from embryonic chicken brain". J. Biol. Chem. 257 (21): 12765–9. PMID 7130178.