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MOAP1

From Wikipedia, the free encyclopedia

MOAP1
Identifiers
AliasesMOAP1, MAP-1, PNMA4, modulator of apoptosis 1
External IDsOMIM: 609485; MGI: 1915555; HomoloGene: 11154; GeneCards: MOAP1; OMA:MOAP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022151

NM_001142937
NM_022323

RefSeq (protein)

NP_071434

NP_001136409
NP_071718

Location (UCSC)Chr 14: 93.18 – 93.18 MbChr 12: 102.71 – 102.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Modulator of apoptosis 1 is a protein that in humans is encoded by the MOAP1 gene.[5][6]

The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis.[6]

References

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  1. ^ a b c ENSG00000278268 GRCh38: Ensembl release 89: ENSG00000165943, ENSG00000278268Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000096458Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tan KO, Tan KM, Chan SL, Yee KS, Bevort M, Ang KC, Yu VC (May 2001). "MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains". J Biol Chem. 276 (4): 2802–7. doi:10.1074/jbc.M008955200. PMID 11060313.
  6. ^ a b "Entrez Gene: MOAP1 modulator of apoptosis 1".

Further reading

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