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Limulus clotting factor B

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Limulus clotting factor B
Identifiers
EC no.3.4.21.85
CAS no.848851-53-6
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Limulus clotting factor B (EC 3.4.21.85) is an enzyme.[1] This enzyme catalyses the following chemical reaction

Selective cleavage of -Arg98-Ile- bond in limulus proclotting enzyme to form active clotting enzyme

From the hemocyte granules of the horseshoe crabs Limulus and Tachypleus. This enzyme is downstream of Limulus clotting factor C, but upstream of Limulus clotting enzyme.[2]

References

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  1. ^ Nakamura T, Horiuchi T, Morita T, Iwanaga S (March 1986). "Purification and properties of intracellular clotting factor, factor B, from horseshoe crab (Tachypleus tridentatus) hemocytes". Journal of Biochemistry. 99 (3): 847–57. doi:10.1093/oxfordjournals.jbchem.a135545. PMID 3519594.
  2. ^ Iwanaga, S (May 2007). "Biochemical principle of Limulus test for detecting bacterial endotoxins". Proceedings of the Japan Academy. Series B, Physical and Biological Sciences. 83 (4): 110–9. Bibcode:2007PJAB...83..110I. doi:10.2183/pjab.83.110. PMC 3756735. PMID 24019589.
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