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IFT20

From Wikipedia, the free encyclopedia
IFT20
Identifiers
AliasesIFT20, intraflagellar transport 20
External IDsOMIM: 614394; MGI: 1915585; HomoloGene: 49559; GeneCards: IFT20; OMA:IFT20 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018854

RefSeq (protein)

NP_061342

Location (UCSC)Chr 17: 28.33 – 28.34 MbChr 11: 78.43 – 78.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Intraflagellar transport protein 20 homolog is a protein that in humans is encoded by the IFT20 gene.[5] The gene is composed of 6 exons and is located on human chromosome 17p11.1. This gene is expressed in human brain, lung, kidney and pancreas, and lower expression were also detected in human placenta, liver, thymus, prostate and testis.[6]

Intraflagellar transport (IFT), in which molecular motors and IFT particle proteins participate, is very important in assembling and maintaining many cilia/flagella, such as the motile cilia that drive the swimming of cells and embryos, the nodal cilia that generate left-right asymmetry in vertebrate embryos, and the sensory cilia that detect sensory stimuli in some animals.[6] IFT20 subunit of the particle is localized to the Golgi complex in addition to the basal body and cilia where all previous IFT particle proteins had been found. In living cells, fluorescently tagged IFT20 is highly dynamic and moves between the Golgi complex and the cilium as well as along ciliary microtubules.[7] IFT20 has been shown to interact with SPEF2 in the testis, and plays a role in sperm motility.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109083Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001105Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: IFT20 intraflagellar transport 20 homolog (Chlamydomonas)".
  6. ^ a b Yin G, Dai J, Ji C, Ni X, Shu G, Ye X, Dai J, Wu Q, Gu S, Xie Y, Zhao RC, Mao Y (December 2003). "Cloning and characterization of the human IFT20 gene". Mol. Biol. Rep. 30 (4): 255–60. doi:10.1023/A:1026365124176. PMID 14672413. S2CID 11836051.
  7. ^ Follit JA, Tuft RA, Fogarty KE, Pazour GJ (2006). "The Intraflagellar Transport Protein IFT20 Is Associated with the Golgi Complex and Is Required for Cilia Assembly". Mol. Biol. Cell. 17 (9): 3781–92. doi:10.1091/mbc.E06-02-0133. PMC 1593158. PMID 16775004.
  8. ^ Sironen, Anu; Hanse, J.; Thomsen, B.; Andersson, M.; Vilkki, J.; Toppari, J.; Kotaja, N (2010). "Expression of SPEF2 During Mouse Spermatogenesis and Identification of IFT20 as an Interacting Protein". Biology of Reproduction. 82 (3): 580–590. doi:10.1095/biolreprod.108.074971. PMID 19889948.

Further reading

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