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HAP2

From Wikipedia, the free encyclopedia
Male gamete fusion factor
Identifiers
SymbolHAP2-GCS1
PfamPF10699
InterProIPR018928
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

HAP2 (hapless 2), also known as GCS1 (generative cell-specific protein 1), is a family of membrane fusion proteins found in the sperm cell of diverse eukaryotes including Toxoplasma, thale cress, and fruit flies. This protein is essential for gamete fusion, and therefore fertilization, in these organisms. It is a domesticated instance of a viral class II fusion protein.[1]

References

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  1. ^ Fédry J, Liu Y, Péhau-Arnaudet G, Pei J, Li W, Tortorici MA, et al. (February 2017). "The Ancient Gamete Fusogen HAP2 Is a Eukaryotic Class II Fusion Protein". Cell. 168 (5): 904–915.e10. doi:10.1016/j.cell.2017.01.024. PMC 5332557. PMID 28235200.