GSX1
GS homeobox 1 (GSX1) is a protein encoded by a gene of the same name, located on chromosome 13 in humans.[5]
Structure
[edit]GSX1 is a polypeptide chain consisting of 264 amino acids, with a molecular weight of 27,833.[6] GSX1 contain a homeodomain which binds double stranded DNA, and hence is a probable transcription factor.[7]
Function
[edit]The encoded protein is considered an activator and developmental protein. It is involved in biological processes such as transcription and transcription regulation. The protein has a DNA-binding domain and is localized in the cell nucleus.[8]
GSX1 has been shown to play a key role in the expression of the growth hormone-releasing hormone (GHRH) gene. A study demonstrated that the homeobox transcription factor GSX1 (Gsh-1 in mice) is crucial for GHRH gene expression, as evidenced by the dwarf phenotype and abolished GHRH expression in Gsh-1 knockout mice. The research revealed that GSX1 binds to multiple sites in the GHRH promoter, enhancing its transcriptional activity, particularly when co-expressed with CREB-binding protein, indicating a cooperative regulatory mechanism in the hypothalamus.[9]
References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000169840 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053129 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "HUGO Gene Nomenclature Commitee, HGNC:20374". Retrieved 2017-09-20.
{{cite web}}: CS1 maint: url-status (link) - ^ "UniProt, Q9H4S2". Archived from the original on 2017-10-03. Retrieved 2017-09-20.
- ^ "GSX1_HUMAN". UniProt. Q9H4S2.
- ^ "GSX1 GS homeobox 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-10-14.
- ^ Mutsuga N, Iwasaki Y, Morishita M, Nomura A, Yamamori E, Yoshida M, et al. (December 2001). "Homeobox protein Gsh-1-dependent regulation of the rat GHRH gene promoter". Molecular Endocrinology. 15 (12): 2149–2156. doi:10.1210/mend.15.12.0747. PMID 11731616.