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GSTO1

From Wikipedia, the free encyclopedia

GSTO1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGSTO1, GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R, glutathione S-transferase omega 1
External IDsOMIM: 605482; MGI: 1342273; HomoloGene: 37971; GeneCards: GSTO1; OMA:GSTO1 - orthologs
EC number1.20.4.2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004832
NM_001191002
NM_001191003

NM_010362

RefSeq (protein)

NP_001177931
NP_001177932
NP_004823

NP_034492

Location (UCSC)Chr 10: 104.24 – 104.27 MbChr 19: 47.84 – 47.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glutathione S-transferase omega-1 is an enzyme that in humans is encoded by the GSTO1 gene.[5][6][7]

This gene encodes a member of the theta class glutathione S-transferase-like (GSTTL) protein family. In mouse, the encoded protein acts as a small stress response protein, likely involved in cellular redox homeostasis.[7] This protein has dehydroascorbate reductase activity and may function in the glutathione-ascorbate cycle as part of antioxidant metabolism.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000148834Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025068Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Board PG, Coggan M, Chelvanayagam G, Easteal S, Jermiin LS, Schulte GK, et al. (Sep 2000). "Identification, characterization, and crystal structure of the Omega class glutathione transferases". J Biol Chem. 275 (32): 24798–806. doi:10.1074/jbc.M001706200. PMID 10783391.
  6. ^ Whitbread AK, Tetlow N, Eyre HJ, Sutherland GR, Board PG (Mar 2003). "Characterization of the human Omega class glutathione transferase genes and associated polymorphisms". Pharmacogenetics. 13 (3): 131–44. doi:10.1097/00008571-200303000-00003. PMID 12618591.
  7. ^ a b "Entrez Gene: GSTO1 glutathione S-transferase omega 1".
  8. ^ Whitbread AK, Masoumi A, Tetlow N, Schmuck E, Coggan M, Board PG (2005). "Characterization of the Omega Class of Glutathione Transferases". Gluthione Transferases and Gamma-Glutamyl Transpeptidases. Methods in Enzymology. Vol. 401. pp. 78–99. doi:10.1016/S0076-6879(05)01005-0. ISBN 978-0-12-182806-6. PMID 16399380.

Further reading

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