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GSTA2

From Wikipedia, the free encyclopedia
GSTA2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGSTA2, GST2, GSTA2-2, GTA2, GTH2, glutathione S-transferase alpha 2
External IDsOMIM: 138360; MGI: 95863; HomoloGene: 47952; GeneCards: GSTA2; OMA:GSTA2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000846

NM_008182

RefSeq (protein)

NP_000837

NP_032208

Location (UCSC)Chr 6: 52.75 – 52.76 MbChr 9: 78.24 – 78.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glutathione S-transferase A2 is an enzyme that in humans is encoded by the GSTA2 gene.[5]

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000244067Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057933Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: GSTA2 glutathione S-transferase A2".

Further reading

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