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Fatty-acyl-CoA-transporting ATPase

From Wikipedia, the free encyclopedia
peroxisomal fatty acyl CoA transporter
Identifiers
EC no.7.6.2.4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a fatty-acyl-CoA-transporting ATPase (EC 7.6.2.4) is an enzyme that catalyzes the chemical reaction

ATP + H2O + fatty acyl CoAcis ADP + phosphate + fatty acyl CoAtrans

The 3 substrates of this enzyme are ATP, H2O, and fatty acyl CoAcis, whereas its 3 products are ADP, phosphate, and fatty acyl CoAtrans.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (fatty-acyl-CoA-transporting).

References

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  • Kamijo K, Taketani S, Yokota S, Osumi T, Hashimoto T (1990). "The 70-kDa peroxisomal membrane protein is a member of the Mdr (P-glycoprotein)-related ATP-binding protein superfamily". J. Biol. Chem. 265 (8): 4534–40. PMID 1968461.
  • Rodrigues-Pousada C, Wanders RJ, Tabak HF (1996). "The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae". EMBO J. 15 (15): 3813–22. PMC 452064. PMID 8670886.
  • Saier MH Jr (1998). "Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya". Adv. Microb. Physiol. 40: 81–136. doi:10.1016/S0065-2911(08)60130-7. PMID 9889977.