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dTDP-4-dehydro-6-deoxyglucose reductase

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dTDP-4-dehydro-6-deoxyglucose reductase
Identifiers
EC no.1.1.1.266
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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In enzymology, a dTDP-4-dehydro-6-deoxyglucose reductase (EC 1.1.1.266) is an enzyme that catalyzes the chemical reaction

dTDP-D-fucose + NADP+ dTDP-4-dehydro-6-deoxy-D-glucose + NADPH + H+

Thus, the two substrates of this enzyme are dTDP-D-fucose and NADP+, whereas its 3 products are dTDP-4-dehydro-6-deoxy-D-glucose, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is dTDP-D-fucose:NADP+ oxidoreductase. This enzyme is also called dTDP-4-keto-6-deoxyglucose reductase. This enzyme participates in polyketide sugar unit biosynthesis.

References

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  • Yoshida Y, Nakano Y, Nezu T, Yamashita Y, Koga T (1999). "A novel NDP-6-deoxyhexosyl-4-ulose reductase in the pathway for the synthesis of thymidine diphosphate-D-fucose". J. Biol. Chem. 274 (24): 16933–9. doi:10.1074/jbc.274.24.16933. PMID 10358040.