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DEFB104A

From Wikipedia, the free encyclopedia
DEFB104A
Identifiers
AliasesDEFB104A, BD-4, DEFB-4, DEFB104, DEFB4, hBD-4, defensin beta 104A
External IDsHomoloGene: 88640; GeneCards: DEFB104A; OMA:DEFB104A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_080389

n/a

RefSeq (protein)

NP_001035792

n/a

Location (UCSC)Chr 8: 7.84 – 7.84 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Beta-defensin 104 is a protein that in humans is encoded by the DEFB104A gene.[3]

Function

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Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 104, DEFB104A and DEFB104B, in head-to-head orientation. This gene, DEFB104A, represents the more centromeric copy.[3]

References

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  1. ^ a b c ENSG00000285034 GRCh38: Ensembl release 89: ENSG00000176782, ENSG00000285034Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: DEFB104A defensin, beta 104A".

Further reading

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