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Cysteine—tRNA ligase

From Wikipedia, the free encyclopedia
Cysteine—tRNA ligase
Identifiers
EC no.6.1.1.16
CAS no.37318-56-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a cysteine—tRNA ligase (EC 6.1.1.16) is an enzyme that catalyzes the chemical reaction

ATP + L-cysteine + tRNACys AMP + diphosphate + L-cysteinyl-tRNACys

The 3 substrates of this enzyme are ATP, L-cysteine, and tRNA(Cys), whereas its 3 products are AMP, diphosphate, and L-cysteinyl-tRNA(Cys).

This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-cysteine:tRNACys ligase (AMP-forming). Other names in common use include cysteinyl-tRNA synthetase, cysteinyl-transferRNA synthetase, cysteinyl-transfer ribonucleate synthetase, and cysteine translase. This enzyme participates in cysteine metabolism and aminoacyl-trna biosynthesis.

Structural studies

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As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1LI5, 1LI7, and 1U0B.

References

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  • Mccorquodale DJ (December 1964). "The separation and partial purification of aminoacyl-RNA synthetases from Escherichia coliI". Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects. 91 (4): 541–8. doi:10.1016/0926-6550(64)90001-5. PMID 14262440.