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CTPS2

From Wikipedia, the free encyclopedia
CTPS2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCTPS2, CTP synthase 2, GATD5B
External IDsOMIM: 300380; MGI: 1933185; HomoloGene: 115908; GeneCards: CTPS2; OMA:CTPS2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001144002
NM_019857
NM_175859

NM_001168568
NM_001168569
NM_001168571
NM_018737
NM_001358398

RefSeq (protein)

NP_001137474
NP_062831
NP_787055

NP_001162040
NP_001162041
NP_001162043
NP_061207
NP_001345327

Location (UCSC)Chr X: 16.59 – 16.71 MbChr X: 161.68 – 161.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CTP synthase 2 is an enzyme that in humans is encoded by the CTPS2 gene.[5][6]

The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate.

This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein.

Thus, this protein is an attractive target for selective chemotherapy. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000047230Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031360Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ van Kuilenburg AB, Meinsma R, Vreken P, Waterham HR, van Gennip AH (Oct 2000). "Identification of a cDNA encoding an isoform of human CTP synthetase". Biochim Biophys Acta. 1492 (2–3): 548–52. doi:10.1016/s0167-4781(00)00141-x. PMID 10899599.
  6. ^ a b "Entrez Gene: CTPS2 CTP synthase II".
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Further reading

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