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CPD (gene)

From Wikipedia, the free encyclopedia
CPD
Identifiers
AliasesCPD, GP180, carboxypeptidase D
External IDsOMIM: 603102; MGI: 107265; HomoloGene: 999; GeneCards: CPD; OMA:CPD - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001199775
NM_001304

NM_007754

RefSeq (protein)

NP_001186704
NP_001295

NP_031780

Location (UCSC)Chr 17: 30.38 – 30.47 MbChr 11: 76.67 – 76.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carboxypeptidase D is an enzyme that in humans is encoded by the CPD gene.[5][6][7]

Function

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The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities: the pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108582Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020841Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Riley DA, Tan F, Miletich DJ, Skidgel RA (May 1998). "Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1)". Genomics. 50 (1): 105–8. doi:10.1006/geno.1998.5295. PMID 9628828.
  6. ^ Tan F, Rehli M, Krause SW, Skidgel RA (Oct 1997). "Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem active site domains". The Biochemical Journal. 327 ( Pt 1) (Pt 1): 81–7. doi:10.1042/bj3270081. PMC 1218766. PMID 9355738.
  7. ^ a b "Entrez Gene: CPD carboxypeptidase D".

Further reading

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