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CNOT4

From Wikipedia, the free encyclopedia

CNOT4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCNOT4, CLONE243, NOT4, NOT4H, CCR4-NOT transcription complex subunit 4
External IDsOMIM: 604911; MGI: 1859026; HomoloGene: 40870; GeneCards: CNOT4; OMA:CNOT4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001164411
NM_001164412
NM_001164413
NM_001164414
NM_016877

RefSeq (protein)

NP_001157883
NP_001157884
NP_001157885
NP_001157886
NP_058573

Location (UCSC)Chr 7: 135.36 – 135.51 MbChr 6: 35 – 35.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CCR4-NOT transcription complex, subunit 4 is a protein that in humans is encoded by the CNOT4 gene.[5]

Function

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The protein encoded by this gene is a subunit of the CCR4-Not complex, a global transcriptional regulator and deadenylase. The encoded protein interacts with CNOT1 and has ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]. Diseases associated with CNOT4 include Adenoiditis.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000080802Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038784Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CCR4-NOT transcription complex, subunit 4".
  6. ^ "CNOT4 Gene - GeneCards | CNOT4 Protein | CNOT4 Antibody". www.genecards.org. Retrieved 2019-06-21.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.