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CEACAM16

From Wikipedia, the free encyclopedia

CEACAM16
Identifiers
AliasesCEACAM16, CEAL2, DFNA4B, carcinoembryonic antigen related cell adhesion molecule 16, DFNB113, CEA cell adhesion molecule 16, tectorial membrane component
External IDsOMIM: 614591; MGI: 2685615; HomoloGene: 19857; GeneCards: CEACAM16; OMA:CEACAM16 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001039213

NM_001033419

RefSeq (protein)

NP_001034302

NP_001028591

Location (UCSC)Chr 19: 44.7 – 44.71 MbChr 7: 19.59 – 19.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carcinoembryonic antigen-related cell adhesion molecule 16 is encoded in the human by the CEACAM16 gene. It is a member of the carcinoembryonic antigen family, a cluster of genes on chromosome 19. CEACAM16 is a structure of the tectorial membrane involved in hearing at low and high frequencies. It is the only carcinoembryonic antigen found in the platypus.[5] The protein is expressed in mammalian outer hair cells, and mutations in this gene are associated with autosomal dominant nonsyndromic deafness.[6][7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000213892Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014686Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kammerer R, Rüttiger L, Riesenberg R, Schäuble C, Krupar R, Kamp A, et al. (June 2012). "Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies". The Journal of Biological Chemistry. 287 (26): 21584–21598. doi:10.1074/jbc.M111.320481. PMC 3381124. PMID 22544735.
  6. ^ Zheng J, Miller KK, Yang T, Hildebrand MS, Shearer AE, DeLuca AP, et al. (March 2011). "Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4)". Proceedings of the National Academy of Sciences of the United States of America. 108 (10): 4218–4223. Bibcode:2011PNAS..108.4218Z. doi:10.1073/pnas.1005842108. PMC 3054008. PMID 21368133.
  7. ^ Hofrichter MA, Nanda I, Gräf J, Schröder J, Shehata-Dieler W, Vona B, Haaf T (October 2015). "A Novel de novo Mutation in CEACAM16 Associated with Postlingual Hearing Impairment". Molecular Syndromology. 6 (4): 156–163. doi:10.1159/000439576. PMC 4662267. PMID 26648831.