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BRD8

From Wikipedia, the free encyclopedia
BRD8
Identifiers
AliasesBRD8, SMAP, SMAP2, p120, bromodomain containing 8
External IDsOMIM: 602848; MGI: 1925906; HomoloGene: 41790; GeneCards: BRD8; OMA:BRD8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001289606
NM_001289607
NM_030147
NM_001361136

RefSeq (protein)

NP_001276535
NP_001276536
NP_084423
NP_001348065

Location (UCSC)Chr 5: 138.14 – 138.18 MbChr 18: 34.73 – 34.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bromodomain-containing protein 8 is a protein that in humans is encoded by the BRD8 gene.[5][6][7]

The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode distinct isoforms have been identified.[7]

Interactions

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BRD8 has been shown to interact with Thyroid hormone receptor beta[6] and Retinoid X receptor alpha.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112983Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003778Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nielsen MS, Petersen CM, Gliemann J, Madsen P (April 1996). "Cloning and sequencing of a human cDNA encoding a putative transcription factor containing a bromodomain". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1306 (1): 14–6. doi:10.1016/0167-4781(95)00239-1. PMID 8611617.
  6. ^ a b Monden T, Wondisford FE, Hollenberg AN (November 1997). "Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein". The Journal of Biological Chemistry. 272 (47): 29834–41. doi:10.1074/jbc.272.47.29834. PMID 9368056.
  7. ^ a b "Entrez Gene: BRD8 bromodomain containing 8".
  8. ^ Monden T, Kishi M, Hosoya T, Satoh T, Wondisford FE, Hollenberg AN, Yamada M, Mori M (October 1999). "p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers". Molecular Endocrinology. 13 (10): 1695–703. doi:10.1210/mend.13.10.0353. PMID 10517671. S2CID 25098867.
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Further reading

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