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Anion exchange transporter

From Wikipedia, the free encyclopedia
SLC26A7
Identifiers
AliasesSLC26A7, SUT2, solute carrier family 26 member 7
External IDsOMIM: 608479; MGI: 2384791; HomoloGene: 13770; GeneCards: SLC26A7; OMA:SLC26A7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_134266
NM_001282356
NM_001282357
NM_052832

NM_145947

RefSeq (protein)

NP_001269285
NP_001269286
NP_439897
NP_599028

NP_666059

Location (UCSC)Chr 8: 91.21 – 91.4 MbChr 4: 14.5 – 14.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Anion exchange transporter is a protein that in humans is encoded by the SLC26A7 gene.[5][6][7][8]

Function

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This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. This gene has abundant and specific expression in the kidney. Splice variants that use both alternate transcription initiation and polyadenylation sites have been described for this gene.[8]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147606Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040569Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J (April 2002). "Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9". The Journal of Biological Chemistry. 277 (16): 14246–54. doi:10.1074/jbc.M111802200. PMID 11834742.
  6. ^ Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP (February 2002). "Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney". Genomics. 79 (2): 249–56. doi:10.1006/geno.2002.6689. PMID 11829495.
  7. ^ Xu J, Worrell RT, Li HC, Barone SL, Petrovic S, Amlal H, Soleimani M (April 2006). "Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion". Journal of the American Society of Nephrology. 17 (4): 956–67. doi:10.1681/ASN.2005111174. PMID 16524946.
  8. ^ a b "Entrez Gene: SLC26A7 solute carrier family 26, member 7".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.