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23S rRNA (cytosine1962-C5)-methyltransferase

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23S rRNA (cytosine1962-C5)-methyltransferase
Identifiers
EC no.2.1.1.191
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
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NCBIproteins

23S rRNA (cytosine1962-C5)-methyltransferase (EC 2.1.1.191, RlmI, rRNA large subunit methyltransferase I, YccW) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (cytosine1962-C5)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + cytosine1962 in 23S rRNA S-adenosyl-L-homocysteine + 5-methylcytosine1962 in 23S rRNA

The enzyme specifically methylates cytosine1962 at C5 in 23S rRNA.

References

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  1. ^ Purta E, O'Connor M, Bujnicki JM, Douthwaite S (November 2008). "YccW is the m5C methyltransferase specific for 23S rRNA nucleotide 1962". Journal of Molecular Biology. 383 (3): 641–51. doi:10.1016/j.jmb.2008.08.061. PMID 18786544.
  2. ^ Sunita S, Tkaczuk KL, Purta E, Kasprzak JM, Douthwaite S, Bujnicki JM, Sivaraman J (November 2008). "Crystal structure of the Escherichia coli 23S rRNA:m5C methyltransferase RlmI (YccW) reveals evolutionary links between RNA modification enzymes". Journal of Molecular Biology. 383 (3): 652–66. doi:10.1016/j.jmb.2008.08.062. PMID 18789337.
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