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TAF1C

From Wikipedia, the free encyclopedia
TAF1C
Identifiers
AliasesTAF1C, MGC:39976, SL1, TAFI110, TAFI95, TATA-box binding protein associated factor, RNA polymerase I subunit C
External IDsOMIM: 604905; MGI: 109576; HomoloGene: 21163; GeneCards: TAF1C; OMA:TAF1C - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021441
NM_001378901

RefSeq (protein)

NP_067416
NP_001365830

Location (UCSC)Chr 16: 84.18 – 84.19 MbChr 8: 120.32 – 120.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TATA box-binding protein-associated factor RNA polymerase I subunit C is an enzyme that in humans is encoded by the TAF1C gene.[5][6]

Function

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Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.[6]

Interactions

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TAF1C has been shown to interact with UBTF.[7][8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103168Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031832Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R (1994). "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits". Science. 266 (5193): 1966–72. Bibcode:1994Sci...266.1966C. doi:10.1126/science.7801123. PMID 7801123.
  6. ^ a b "Entrez Gene: TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa".
  7. ^ Voit R, Grummt I (November 2001). "Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13631–6. Bibcode:2001PNAS...9813631V. doi:10.1073/pnas.231071698. PMC 61092. PMID 11698641.
  8. ^ Zhai W, Comai L (August 2000). "Repression of RNA polymerase I transcription by the tumor suppressor p53". Mol. Cell. Biol. 20 (16): 5930–8. doi:10.1128/MCB.20.16.5930-5938.2000. PMC 86070. PMID 10913176.

Further reading

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