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English: Interaction of The Glucocorticoid Receptor with DNA Edit this at Structured Data on Commons
Date 24 July 2007 (original upload date)
Source
  • Own work (Original caption: "
    Created myself using PyMol
    ")
  • Transferred from en.wikipedia by SreeBot
Author Boghog at en.wikipedia

Two crystal structures of the glucocorticoid receptor DNA-binding domain complexed with DNA are reported. The domain has a globular fold which contains two Zn-nucleated substructures of distinct conformation and function. When it binds DNA, the domain dimerizes, placing the subunits in adjacent major grooves. In one complex, the DNA has the symmetrical consensus target sequence; in the second, the central spacing between the target's half-sites is larger by one base pair. This results in one subunit interacting specifically with the consensus target half-site and the other nonspecifically with a noncognate element. The DNA-induced dimer fixes the separation of the subunits' recognition surfaces so that the spacing between the half-sites becomes a critical feature of the target sequence's identity. Reference Crystallographic Analysis of the Interaction of The Glucocorticoid Receptor with DNA Luisi, B.F., Xu, W.X., Otwinowski, Z., Freedman, L.P., Yamamoto, K.R., Sigler, P.B. (1991) Nature 352: 497-505

PubMed: 1865905 Search on PubMed DOI: https://doi.org/10.1038/352497a0 Primary Citation of Related Structures: 1GLU, 1R4O, 1R4R

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Upload date | User | Bytes | Dimensions | Comment

  • 2007-09-07 05:27 (UTC) | Boghog | 265194 (bytes) | 960×720 | Created myself using PyMol
  • 2007-07-24 19:18 (UTC) | Boghog | 193395 (bytes) | 960×720 | Created myself using PyMol

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Interaction of The Glucocorticoid Receptor with DNA

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24 July 2007

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75f674706b0193de13ef6547d17450855bc17535

263,047 byte

720 pixel

960 pixel

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Date/TimeThumbnailDimensionsUserComment
current08:33, 5 November 2011Thumbnail for version as of 08:33, 5 November 2011960 × 720 (257 KB)Smaug the GoldenNew version
18:33, 1 August 2011Thumbnail for version as of 18:33, 1 August 2011960 × 720 (259 KB)OgreBot(BOT): Reverting to most recent version; originally uploaded at en.wikipedia on 2007-09-07 05:27:41 by Boghog
18:33, 1 August 2011Thumbnail for version as of 18:33, 1 August 2011960 × 720 (189 KB)OgreBot(BOT): Uploading old version of file from en.wikipedia; originally uploaded on 2007-07-24 19:18:07 by Boghog
12:02, 1 August 2011Thumbnail for version as of 12:02, 1 August 2011960 × 720 (259 KB)SreeBot

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