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C-C motif chemokine ligand 27

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(Redirected from CCL27)
CCL27
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCCL27, ALP, CTACK, CTAK, ESKINE, ILC, PESKY, SCYA27, C-C motif chemokine ligand 27
External IDsOMIM: 604833; MGI: 1891389; HomoloGene: 104838; GeneCards: CCL27; OMA:CCL27 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006664

NM_001199959
NM_001199960
NM_001199961

RefSeq (protein)

NP_006655

Location (UCSC)Chr 9: 34.66 – 34.66 MbChr 4: 42.66 – 42.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
chemokine (C-C motif) ligand 27
Identifiers
SymbolCCL27
Alt. symbolsSCYA27, ALP, ILC, CTACK, skinkine, ESkine, PESKY, CTAK
NCBI gene10850
HGNC10626
OMIM604833
RefSeqNM_006664
UniProtQ9Y4X3
Other data
LocusChr. 9 q13
Search for
StructuresSwiss-model
DomainsInterPro

C-C motif chemokine ligand 27 is a protein that in humans is encoded by the CCL27 gene. [5]

Function

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This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. CCL27 is associated with homing of memory T lymphocytes to the skin, and plays a role in T cell-mediated inflammation of the skin.[6][7] CCL27 is expressed in numerous tissues, including gonads, thymus, placenta and skin. It elicits its chemotactic effects by binding to the chemokine receptor CCR10.[8] The gene for CCL27 is located on human chromosome 9.[9] Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Sep 2014].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000213927Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000096826Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: C-C motif chemokine ligand 27". Retrieved 2018-03-23.
  6. ^ Morales et al. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc. Natl. Acad. Sci. U.S.A. 96:14470-14475, 1999.
  7. ^ Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, et al. (February 2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nature Medicine. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID 11821900. S2CID 35433583.
  8. ^ Homey B, Wang W, Soto H, Buchanan ME, Wiesenborn A, Catron D, et al. (April 2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". Journal of Immunology. 164 (7): 3465–70. doi:10.4049/jimmunol.164.7.3465. PMID 10725697.
  9. ^ Ishikawa-Mochizuki I, Kitaura M, Baba M, Nakayama T, Izawa D, Imai T, et al. (November 1999). "Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus". FEBS Letters. 460 (3): 544–8. Bibcode:1999FEBSL.460..544I. doi:10.1016/s0014-5793(99)01406-4. PMID 10556532. S2CID 39019419.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.