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Cysteine protease ATG4A

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ATG4A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesATG4A, APG4A, AUTL2, autophagy related 4A cysteine peptidase, HsAPG4A
External IDsOMIM: 300663; MGI: 2147903; HomoloGene: 70873; GeneCards: ATG4A; OMA:ATG4A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_174875

RefSeq (protein)

NP_777364
NP_001366610
NP_001366611
NP_001366612
NP_001366613

Location (UCSC)Chr X: 108.09 – 108.15 MbChr X: 140.96 – 141.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cysteine protease ATG4A is an enzyme that in humans is encoded by the ATG4A gene.[5][6]

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodelling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101844Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079418Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Scherz-Shouval R, Sagiv Y, Shorer H, Elazar Z (Apr 2003). "The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A". J Biol Chem. 278 (16): 14053–8. doi:10.1074/jbc.M212108200. PMID 12473658.
  6. ^ a b "Entrez Gene: ATG4A ATG4 autophagy related 4 homolog A (S. cerevisiae)".
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Further reading

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