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23S rRNA pseudouridine746 synthase

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23S rRNA pseudouridine746 synthase
Identifiers
EC no.5.4.99.29
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
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MetaCycmetabolic pathway
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NCBIproteins

23S rRNA pseudouridine746 synthase (EC 5.4.99.29, RluA, 23S RNA PSI746 synthase, 23S rRNA pseudouridine synthase, pseudouridine synthase RluA) is an enzyme with systematic name 23S rRNA-uridine746 uracil mutase.[1][2][3] This enzyme catalyses the following chemical reaction

23S rRNA uridine746 23S rRNA pseudouridine746

RluA is the only protein responsible for the in vivo formation of 23S RNA pseudouridine746.

References

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  1. ^ Hoang C, Chen J, Vizthum CA, Kandel JM, Hamilton CS, Mueller EG, Ferré-D'Amaré AR (November 2006). "Crystal structure of pseudouridine synthase RluA: indirect sequence readout through protein-induced RNA structure". Molecular Cell. 24 (4): 535–45. doi:10.1016/j.molcel.2006.09.017. PMID 17188032.
  2. ^ Raychaudhuri S, Niu L, Conrad J, Lane BG, Ofengand J (July 1999). "Functional effect of deletion and mutation of the Escherichia coli ribosomal RNA and tRNA pseudouridine synthase RluA". The Journal of Biological Chemistry. 274 (27): 18880–6. doi:10.1074/jbc.274.27.18880. PMID 10383384.
  3. ^ Wrzesinski J, Nurse K, Bakin A, Lane BG, Ofengand J (June 1995). "A dual-specificity pseudouridine synthase: an Escherichia coli synthase purified and cloned on the basis of its specificity for psi 746 in 23S RNA is also specific for psi 32 in tRNA(phe)". RNA. 1 (4): 437–48. PMC 1482406. PMID 7493321.
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